Yes, you can take a scenic cruise along the Mekong River from Phnom Penh to Ho Chi Minh City (Saigon), typically lasting 4 to 6 days. 

These cruises offer immersive experiences through the heart of the Mekong Delta, showcasing the rich cultures and landscapes of both Cambodia and Vietnam. Remember that a Vietnamese & Cambodian visa is required.

Phnom Penh - Saigon cruises often explore the rich landscape of the Mekong Delta. Common stops include:

• Phnom Penh City (depending on the itinerary): Explore the grandeur of the Royal Palace & Silver Pagoda.
• Chau Doc: A border town with charming cultural diversity.
• Tan Chau: Known for traditional crafts and floating fish farms.
• Sa Dec: Famous for its vibrant flower markets and the historic Huynh Thuy Le Ancient House.
• Tien Giang: Home to bustling Cai Be floating village and pretty Tan Phong Islet.
• Can Tho: A developed city with various temples and local handicraft villages.
• Saigon (Ho Chi Minh City): Bustling city with vibrant nightlife.

Below are the top Phnom Penh - Saigon cruises, based on prices and customer reviews:

• Victoria Mekong Cruise 5 days (from US$ 1,092/pax): Pass through various cultural and historical destinations
• RV Mekong Princess Cruise 6 days (from US$ 1,812/pax): Indulge in the serenity and unspoiled allure of Phnom Penh.
• Mekong Eyes Explorer 4 days (from US$ 591/pax): Visit the most beautiful and colorful areas in the Mekong Delta
• Heritage Line Jayavarman Cruise 4 days (from US$ 1,229/pax): Try regional specialties and learn about the fascinating culture

Cambodia Visa 

All Europeans need a Visa to enter Cambodia. Travelers have to get a Visa on Arrival (VOA):

• Available at: Major international airports (Phnom Penh, Siem Reap, Sihanoukville) and certain land borders
• Validity: 30 days (Tourist Visa - T class)
• Requirements: Valid passport (at least 6 months validity), 01 passport-sized photo, Visa fee (around £28 - £33/person), and completed visa application form (available at the airport/land border).

Vietnam Visa

Vietnam has visa exemptions for some European countries for up to 30 or 45 days. You can check your Visa requirements by typing your nationality here.

We strongly recommend applying for a Vietnam e-Visa in advance at: https://evisa.gov.vn/, or through a reputable agency such as BestPrice Travel (€35/person) for a quick and easier process.

NOTE: Make sure your passport is valid for at least 6 months beyond your entry date. 

A cruise from Phnom Penh to Saigon can cost from €136 to €289/person/day. It varies based on the itinerary and the service provided. 

Here are some of the prices for reference (transportation fee excluded):

• 4 days: From €523 - €1089/person.
• 5 - 6 days: From €1135 - €1947/person.