Yes, you can cruise from Phnom Penh to Siem Reap, but the route can alter depending on the water level. 

During the high water season (August to November), cruise ships can navigate Tonle Sap Lake and its attractions. In the low water season (December to mid-August), large cruise vessels cannot cross the lake, so the route will be different.

Let’s remember to check with the cruise operator to confirm the itinerary based on water levels.

A Mekong River cruise from Phnom Penh to Siem Reap often takes 3 to 5 days. The stops can vary depending on the water level. 

• Low-water season: Kampong Tralach, Angkor Ban, Kampong Cham, etc.
• High-water season: Prek Bangkong, Kampong Laeang, Tonle Lake, etc.

A cruise from Phnom Penh to Siem Reap often costs between US$216 and $798/pax/day (excluding the transfer fee). The price can be different based on the itinerary and the service provided.

Cruises from Phnom Penh to Siem Reap do not include a trip to Angkor Wat. They usually disembark at Siem Reap port. You can contact your travel agent to book a separate tour to explore Angkor Wat after you finish the cruise.

Below are the top Phnom Penh - Siem Reap cruises, based on price, US customers’ reviews, and services:

• Heritage Line Jahan 5 days (from US$ 1,482/pax): Bestseller luxury cruise in the Mekong River.
• Heritage Line Jayavarman 5 days (from US$ 1,510/pax): Engaging culinary events, jacuzzi, spa, cultural lectures, etc.
• Aqua Mekong Discovery 4 days (from US$ 3,192/pax): All-inclusive luxury cruise ship.
• RV Mekong Navigator 4 days (from US$ 1,104/pax): Exciting cultural activities and flavorful cuisine.
• Neang Neakii Cruise 3 days (from US$ 714/pax): Cozy boutique boat with Cambodian style décor.

To apply for a Cambodia visa, US citizens have a few different options below. 

Visa on Arrival (VOA)

• Available at: Major international airports (Phnom Penh, Siem Reap, Sihanoukville) and certain land borders
• Validity: 30 days (Tourist Visa - T class)
• Requirements: Valid passport (at least 6 months validity), 01 passport-sized photo, Visa fee (usually around $30 - $35), and completed visa application form (available at the airport/land border)

E-Visa (Online Application)

• Apply at: https://www.evisa.gov.kh
• Validity: 30 days
• Processing time: Usually 3 business days
• Cost: Around $36 (including processing fee)
• Requirements: Digital passport photo, valid passport, and credit/debit card for payment

Note: E-visa is only valid at certain entry points, including Phnom Penh, Siem Reap, and Sihanoukville airports.